Abstract:
ObjectiveTo analyze the etiologic characteristics of three meningococcal meningitis cases in infants in Shanxi province in 2017.
MethodsEpidemiological data and clinical samples of suspected meningococcal meningitis cases were collected. Cerebrospinal fluid and blood specimens were used for the culture, isolation, identification of Neisseria meningitidis. Serogroup identification of N. meningitidis isolates were confirmed by slide agglutination test with serogroup B antiserum. Multi locus sequence typing (MLST) was used for molecular typing and E-test method was used for antimicrobial resistance test.
ResultsThree meningococcal meningitis cases were aged 12 d, 5 months and 8 months, respectively, showing symptoms of purulent meningitis. Three N. meningitidis B strains were isolated, in which two belonged to ST-5664 (Clonal Complex 4821, CC4821) and one belonged to ST-5662 indicated by MLST. All the serogroup B isolates were resistant to ciprofloxacin, levofloxacin and sulfonamides.
ConclusionThree meningococcal meningitis cases caused by N. meningitidis B occurred in Shanxi in 2017, the cases were all infants. It was the first time to isolate N. meningitidis B from case specimens in Shanxi, the major sequence type of the strains belonged to CC4821.