郭金丽, 周忠新, 程古月, 王玉莲, 黄玲利, 熊科香, 黄啸, 刘春贝, 郝海红. 弯曲菌对抗菌药和生物消杀剂耐药和适应机制的研究进展[J]. 疾病监测, 2020, 35(7): 656-663. DOI: 10.3784/j.issn.1003-9961.2020.07.022
引用本文: 郭金丽, 周忠新, 程古月, 王玉莲, 黄玲利, 熊科香, 黄啸, 刘春贝, 郝海红. 弯曲菌对抗菌药和生物消杀剂耐药和适应机制的研究进展[J]. 疾病监测, 2020, 35(7): 656-663. DOI: 10.3784/j.issn.1003-9961.2020.07.022
Jinli Guo, Zhongxin Zhou, Guyue Cheng, Yulian Wang, Lingli Huang, Kexiang Xiong, Xiao Huang, Chunbei Liu, Haihong Hao. Progress in research of resistance and adaptation mechanisms of Campylobacter to antibiotics and biocides[J]. Disease Surveillance, 2020, 35(7): 656-663. DOI: 10.3784/j.issn.1003-9961.2020.07.022
Citation: Jinli Guo, Zhongxin Zhou, Guyue Cheng, Yulian Wang, Lingli Huang, Kexiang Xiong, Xiao Huang, Chunbei Liu, Haihong Hao. Progress in research of resistance and adaptation mechanisms of Campylobacter to antibiotics and biocides[J]. Disease Surveillance, 2020, 35(7): 656-663. DOI: 10.3784/j.issn.1003-9961.2020.07.022

弯曲菌对抗菌药和生物消杀剂耐药和适应机制的研究进展

Progress in research of resistance and adaptation mechanisms of Campylobacter to antibiotics and biocides

  • 摘要: 弯曲菌,特别是空肠弯曲菌,是世界三大食源性病原菌之一,其对抗菌药和生物消杀剂耐药性的产生和传播是食品安全关注的重点。 与敏感菌株相比,细菌获得耐药性后其生长力、体内外定植力和致病力等方面会出现一系列的生理变化,即产生适应性,以便更好地在特定条件下生存。 适应性的强弱决定了耐药菌在宿主和环境中流行扩散的风险。 本研究综述了弯曲菌对主要抗菌药和生物消杀剂的耐药性和适应性机制,为预防和控制弯曲菌耐药性流行和扩散提供理论支撑。

     

    Abstract: Campylobacter, especially C. jejuni, is one of the three foodborne pathogens in the world. The production and spread of its antibiotic and biocide resistances is the focus of food safety. Compared with sensitive strains, after acquiring drug resistance, a series of physiological changes of bacteria, such as growth ability, in vitro and in vivo colonization and pathogenicity, will occur to develop adaptability for better survival under certain conditions. The strength of adaptability determines the risk of drug-resistant bacteria spreading in host and environment. This paper summarizes the resistance and adaptation mechanisms of Campylobacter to major antibiotics and biocides to provide theoretical support for the prevention and control of the prevalence and spread of antibiotic resistance of Campylobacter.

     

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