史雯, 周洋, 袁辰, 严睿, 唐学雯, 何寒青, 邓璇. 2018年浙江省健康人群乙型肝炎血清流行病学调查分析[J]. 疾病监测, 2020, 35(10): 904-908. DOI: 10.3784/j.issn.1003-9961.2020.10.009
引用本文: 史雯, 周洋, 袁辰, 严睿, 唐学雯, 何寒青, 邓璇. 2018年浙江省健康人群乙型肝炎血清流行病学调查分析[J]. 疾病监测, 2020, 35(10): 904-908. DOI: 10.3784/j.issn.1003-9961.2020.10.009
Wen Shi, Yang Zhou, Chen Yuan, Rui Yan, Xuewen Tang, Hanqing He, Xuan Deng. Seroepidemiological survey of hepatitis B in healthy population in Zhejiang, 2018[J]. Disease Surveillance, 2020, 35(10): 904-908. DOI: 10.3784/j.issn.1003-9961.2020.10.009
Citation: Wen Shi, Yang Zhou, Chen Yuan, Rui Yan, Xuewen Tang, Hanqing He, Xuan Deng. Seroepidemiological survey of hepatitis B in healthy population in Zhejiang, 2018[J]. Disease Surveillance, 2020, 35(10): 904-908. DOI: 10.3784/j.issn.1003-9961.2020.10.009

2018年浙江省健康人群乙型肝炎血清流行病学调查分析

Seroepidemiological survey of hepatitis B in healthy population in Zhejiang, 2018

  • 摘要:
    目的了解2018年浙江省健康人群乙型肝炎(乙肝)病毒血清标志物流行情况。
    方法按照多阶段整群随机抽样的方法,抽取浙江省11个市及义乌市常住人口(居住6个月及以上)家庭中0~59岁人群进行问卷调查,并采集静脉血2 ml进行乙肝相关抗原抗体检测。
    结果共调查4 194人,乙肝表面抗原(HBsAg)和乙肝表面抗体(HBsAb)阳性率分别为4.58%(192/4 194)和63.92%(2 681/4 194)。<5岁、0~14岁、15~29岁、30~59岁人群HBsAg阳性率随年龄增加呈上升趋势(χ2=85.228,P<0.001),HBsAb阳性率呈现先下降后上升趋势(χ2=110.413,P<0.001)。 调查人群乙肝疫苗接种率为63.02%(2 643/4 194),接种率随年龄的增长呈逐渐下降趋势(χ2=2 229.121,P<0.001)。 多因素logistic分析结果显示,性别、乙肝疫苗接种史是影响成人HBsAg阳性率的主要因素,男性HBsAg阳性率高于女性(OR=1.404,95%CI:1.014~1.944),乙肝疫苗接种史者HBsAg阳性率低于无乙肝疫苗接种史者(OR=0.548,95%CI:0.371~0.810)。
    结论浙江省儿童乙肝防控工作取得显著成绩,但需提高成年人乙肝疫苗接种率,加强乙肝抗原抗体检测,以利于成年人乙肝防控工作。

     

    Abstract:
    ObjectiveTo investigate the serum markers of hepatitis B virus in healthy population in Zhejiang province in 2018.
    MethodsA questionnaire survey was conducted among 0–59 years old people with local residence >6 months who were selected through multistage stratified cluster random sampling, in 11 prefectures (municipality) and Yiwu of Zhejiang, and 2 ml of venous blood was collected from each study subjects for the detections of hepatitis B virus related antigen and antibody.
    ResultsA total of 4 194 people were investigated, the positive rate of HBsAg was 4.58% (192/4 194), and the anti-HBs rate was 63.92% (2 681/4 194). The positive rate of HBsAg in populations aged 0–14, 15–29 and 30–59 years increased with age ( χ2= 85.228, P<0.001). The positive rate of anti-HBs decreased first and then increased ( χ2=110.413, P<0.001). The immunization rate of hepatitis B vaccine was 63.02% (2 643/4 194). The vaccination rates decreased with age (χ2=2 229.121, P<0.001). The results of multivariate logistic analysis showed that gender and immunization history of hepatitis B vaccine were the main factors influencing the positive rate of HBsAg in adults. The positive rate of HBsAg was higher in men than in women (OR=1.404, 95%CI: 1.014–1.944). The positive rate of HBsAg was lower in patients with hepatitis B immunization history than in those without hepatitis B immunization history (OR=0.548, 95%CI: 0.371–0.810).
    ConclusionRemarkable achievements have been made in the prevention and control of hepatitis B in children in Zhejiang. It is beneficial for the prevention and control of hepatitis B in adults by increasing the immunization rate of hepatitis B vaccine and strengthening the detections of hepatitis B virus antigen and antibody in this population.

     

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