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齐倩倩, 沙丹, 李娟, 赵晓菲, 郑东宇, 管红霞. 2012－2018年江苏省无锡市肠炎沙门菌药物敏感性与分子分型研究[J]. 疾病监测, 2020, 35(12): 1146-1151. DOI: 10.3784/j.issn.1003-9961.2020.12.018
引用本文: 齐倩倩, 沙丹, 李娟, 赵晓菲, 郑东宇, 管红霞. 2012－2018年江苏省无锡市肠炎沙门菌药物敏感性与分子分型研究[J]. 疾病监测, 2020, 35(12): 1146-1151. DOI: 10.3784/j.issn.1003-9961.2020.12.018
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Qi Qianqian, Sha Dan, Li Juan, Zhao Xiaofei, Zheng Dongyu, Guan Hongxia. Drug resistance and molecular types of Salmonella Enteritidis in Wuxi, Jiangsu, 2012–2018[J]. Disease Surveillance, 2020, 35(12): 1146-1151. DOI: 10.3784/j.issn.1003-9961.2020.12.018
Citation: Qi Qianqian, Sha Dan, Li Juan, Zhao Xiaofei, Zheng Dongyu, Guan Hongxia. Drug resistance and molecular types of Salmonella Enteritidis in Wuxi, Jiangsu, 2012–2018[J]. Disease Surveillance, 2020, 35(12): 1146-1151. DOI: 10.3784/j.issn.1003-9961.2020.12.018
shu

2012－2018年江苏省无锡市肠炎沙门菌药物敏感性与分子分型研究

Drug resistance and molecular types of Salmonella Enteritidis in Wuxi, Jiangsu, 2012–2018

    摘要
  • 摘要:
      目的   分析2012 — 2018年江苏省无锡市肠炎沙门菌分离株的药物敏感性和分子分型。
      方法   收集2012 — 2018年分离自无锡市食源性疾病监测哨点医院门诊腹泻患者、从业体检人员、食物中毒以及环境水样监测的110株肠炎沙门菌菌株，采用BD Phoenix全自动细菌鉴定/药敏系统测试方案和脉冲场凝胶电泳（PFGE）方法，进行药物敏感性试验和PFGE分子分型分析。
      结果   110株肠炎沙门菌对环丙沙星、厄他培南、亚胺培南、美罗培南、阿奇霉素和头孢他啶/阿维巴坦6种抗生素均敏感，对萘啶酮酸、氨苄西林和氨苄西林/舒巴坦的耐药率较高；77（70.00%）株菌为多重耐药，以耐3种抗生素为主（45.45%，50/110）。PFGE将110株菌分为39个带型，各带型包含1～31株菌，EN17、EN21和EN24为优势带型。
      结论   无锡市肠炎沙门菌耐药状况严重，应引起重视，菌株的分子分型多样，具有优势带型。

     

    Abstract:
      Objective   To investigate the antibiotic resistance and pulsed field gel-electrophoresis (PFGE) patterns of Salmonella Enteritidis strains detected in Wuxi, Jiangsu province, from 2012 to 2018.
      Methods   A total of 110 strains of S. Enteritidis were isolated from diarrhea patients in outpatient departments of food-borne disease surveillance sentinel hospital, people receiving health examinations, food poisoning cases and environmental water samples in Wuxi from 2012 to 2018. Based on BD Phoenix automatic bacterial identification/susceptibility system test program and PulseNet China network laboratory standard method, we analyzed the drug susceptibilities and PFGE patterns of the 110 strains.
      Results   The 110 strains of S. Enteritidis were sensitive to ciprofloxacin, ertapenem, imipenem, meropenem, azithromycin and ceftazidime/avibactam, but showed high resistance to nalidixic acid, ampicillin and ampicillin/sulbactam. Multidrug resistances were observed in 77 strains (70.00%), and the majority of them were resistant to 3 kinds of antibiotics (45.45%, 50/110). The 110 strains were divided into 39 PFGE patterns by Xba Ⅰ. Each pattern contained 1–31 strains. EN17, EN21 and EN24 were the main PFGE patterns.
      Conclusion   S. Enteritidis strains isolated in Wuxi showed serious drug resistances, and close attention should be paid to its multidrug resistance. The PFGE patterns of the strains showed diversity and predominant patterns existed.

     

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