唐萍, 杜倩倩, 曾海玲, 袁林, 高薇, 刘丹丹, 贾举, 姚开虎. 四川省中江县医院192株肺炎链球菌的血清型和耐药性研究[J]. 疾病监测, 2021, 36(2): 147-151. DOI: 10.3784/jbjc.202010090342
引用本文: 唐萍, 杜倩倩, 曾海玲, 袁林, 高薇, 刘丹丹, 贾举, 姚开虎. 四川省中江县医院192株肺炎链球菌的血清型和耐药性研究[J]. 疾病监测, 2021, 36(2): 147-151. DOI: 10.3784/jbjc.202010090342
Tang Ping, Du Qianqian, Zeng Hailing, Yuan Lin, Gao Wei, Liu Dandan, Jia Ju, Yao Kaihu. Serotype and drug resistance of 192 isolates of Streptococcus pneumoniae, a study in Zhongjiang County People's Hospital, Sichuan[J]. Disease Surveillance, 2021, 36(2): 147-151. DOI: 10.3784/jbjc.202010090342
Citation: Tang Ping, Du Qianqian, Zeng Hailing, Yuan Lin, Gao Wei, Liu Dandan, Jia Ju, Yao Kaihu. Serotype and drug resistance of 192 isolates of Streptococcus pneumoniae, a study in Zhongjiang County People's Hospital, Sichuan[J]. Disease Surveillance, 2021, 36(2): 147-151. DOI: 10.3784/jbjc.202010090342

四川省中江县医院192株肺炎链球菌的血清型和耐药性研究

Serotype and drug resistance of 192 isolates of Streptococcus pneumoniae, a study in Zhongjiang County People's Hospital, Sichuan

  • 摘要:
      目的  分析四川省中江县医院分离的全年龄段住院患者来源的肺炎链球菌的血清型分布以及耐药性状况。
      方法  以2018年11月至2019年6月分离的肺炎链球菌菌株为研究对象;采用荚膜肿胀试验检测血清型;采用E-test法或纸片扩散法检测青霉素等11种抗菌药物的敏感性。
      结果  192株肺炎链球菌共鉴定出26种血清型。 最常见血清型为19A型(41株,21.35%),其次为19F(37株,19.27%)、6B(17株,8.85%)、23F(15株,7.81%)、16F(12株,6.25%)和15A型(11株,5.73%),13价肺炎链球菌结合疫苗(PCV13)覆盖率67.19%,23价荚膜多糖疫苗(PPV23)覆盖率68.23%。 随年龄增加,PCV13比例明显减少,从<2岁年龄组的78.05%降低到≥60岁的44.00%,差异有统计学意义。 分离株对口服青霉素的中介率和耐药率分别为56.20%和39.60%;对红霉素耐药率较高(92.43%)。 PCV13型菌株对青霉素的耐药较非PCV13型菌株更为普遍。
      结论  四川省中江县肺炎链球菌临床分离株中PCV13覆盖率较低,且随宿主年龄增加而降低,成年人尤其老年患者可能是非PCV13型的储存库。

     

    Abstract:
      Objective  To analyze the serotype distribution and drug resistance of Streptococcus pneumoniae isolated from hospitalized patients in all age groups in Zhongjiang, Sichuan province.
      Methods  From November 2018 to June 2019, we collected 192 isolates of S. pneumoniae for serotypes identification using Quellung reaction. Antibiotic resistance was tested using E-test or disc diffusion method.
      Results  A total of 26 serotypes of S. pneumoniae were identified in 192 isolates. The most common serotype was 19A (41, 21.35%), followed by 19F (37, 19.27%), 6B (17, 8.85%), 23F (15, 7.81%), 16F (12, 6.25%) and 15A (11, 5.73%). The coverage of PCV13 was 67.19% and the coverage of PPV23 was 68.20%. With the increase of age, the proportion of PCV13 type decreased significantly from 78.05% in age group <2 years to 44.00% in age group ≥60 years, the difference was significant. The intermediate rate and resistance rate of the isolates to oral penicillin were 56.20% and 39.60%, respectively. The resistance rate to erythromycin was high (92.43%). The PCV13 isolates were more resistant to penicillin than the non-PCV13 isolates.
      Conclusion  The coverage rateof PCV13 in Streptococcus pneumoniae clinical isolates from Zhongjiang County, Sichuan Province is low and decreases with the increase of host age. Adults, especially the elderly, may be non-PCV13 repository.

     

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