赵丽兰, 万康林, 柳志文. 宏基因组学在口腔常见慢性感染性疾病中的研究进展[J]. 疾病监测, 2021, 36(3): 292-296. DOI: 10.3784/jbjc.202011170388
引用本文: 赵丽兰, 万康林, 柳志文. 宏基因组学在口腔常见慢性感染性疾病中的研究进展[J]. 疾病监测, 2021, 36(3): 292-296. DOI: 10.3784/jbjc.202011170388
Zhao Lilan, Wan Kanglin, Liu Zhiwen. Progress in application of metagenomics in studying common oral cavity chronic infectious diseases[J]. Disease Surveillance, 2021, 36(3): 292-296. DOI: 10.3784/jbjc.202011170388
Citation: Zhao Lilan, Wan Kanglin, Liu Zhiwen. Progress in application of metagenomics in studying common oral cavity chronic infectious diseases[J]. Disease Surveillance, 2021, 36(3): 292-296. DOI: 10.3784/jbjc.202011170388

宏基因组学在口腔常见慢性感染性疾病中的研究进展

Progress in application of metagenomics in studying common oral cavity chronic infectious diseases

  • 摘要: 口腔中常见的慢性感染性疾病主要包括龋病、牙髓病、根尖周病、牙周病、智齿冠周炎和颌骨骨髓炎等,其发生通常与病原细菌有关,其病原学的研究也主要集中在发现疾病相关病原细菌。 以往由于传统培养技术的限制,对微生物的认识不够全面,认为口腔慢性感染性疾病的发生是由某种特定的致病微生物感染所造成的。 随着宏基因组学(Metagenomics,也译为元基因组学)及其测序技术的出现和发展,大量的口腔微生物被人们所知晓,打破了认识局限,使不同环境下口腔微生物菌群的组成结构及变化、健康及致病微生物种类、特殊种类微生物在疾病发展过程中的作用陆续被发现,这为口腔慢性感染性疾病的防治和诊疗提供了有力的证据。 本文将对宏基因组学技术及其在口腔几种常见慢性感染性疾病中的研究进展进行综述。

     

    Abstract: The common chronic infectious diseases in oral cavity mainly include caries, pulp disease, periapical disease, periodontal disease, wisdom tooth pericoronitis and jaw osteomyelitis, etc. They are usually related to pathogenic bacteria, and the research on the etiology of these disease also focuses on the discovery of disease-related pathogenic bacteria. Due to the limitation of traditional culture technique, researchers had no comprehensive understanding of microorganisms, and believed that oral chronic infectious diseases were caused by a specific pathogenic microorganism. With the emergence and development of metagenomics and its sequencing technique, a large number of oral microorganisms has been discovered, which has broken the limitation of human knowledge and resulted in subsequent founding of oral microbial flora composition and change under different environment, healthy and pathogenic microorganism species, or special species in the disease development process and provided powerful evidence for the prevention and treatment of chronic oral cavity infectious diseases. In this article, we summarize the metagenomics technique and the progress in application of this technique in studying several common chronic oral cavity infectious diseases.

     

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