Abstract: In June 2021, a total of 67 infectious diseases were reported globally, affecting 225 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (225), dengue fever (29), measles (19), poliomyelitis (12) and chikungunya (12). The top five infectious diseases with highest case fatality rates were Ebola virus disease (52.2%), Middle East respiratory syndrome (34.4%), lassa fever (20.0%), plague (11.1%) and meningitis (5.6%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, measles, dengue fever and cholera. The prevalent infectious diseases in Asia were COVID-19 and dengue fever, the prevalent infectious diseases in Africa were COVID-19, cholera, plague, yellow fever and lassa fever, the prevalent infectious diseases in America were COVID-19, dengue fever and chikungunya, the prevalent infectious disease in Europe was COVID-19.