Abstract: In July 2021, a total of 68 infectious diseases were reported globally, affecting 225 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (225), dengue fever (29), measles (22), malaria (9) and poliomyelitis (8). The top five infectious diseases with highest case fatality rates were Middle East respiratory syndrome (34.4%), Lassa fever (20.3%), yellow fever (13.6%), West Nile fever (8.3%) and meningitis (7.7%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, measles, dengue fever and cholera. The prevalent infectious diseases in Asia were COVID-19, dengue fever and cholera, the prevalent infectious diseases in Africa were COVID-19, cholera, yellow fever, Lassa fever, poliomyelitis and measles, the prevalent infectious diseases in America were COVID-19, dengue fever and chikungunya, the prevalent infectious disease in Europe was COVID-19.