Abstract: In April 2022, a total of 69 infectious diseases were reported globally, affecting 232 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (232), dengue fever (29), measles (25), cholera (11) and leptospirosis (9). The top five infectious diseases with highest case fatality rates were Ebola virus disease (100.0%), Crimean-Congo hemorrhagic fever (40.0%), Middle East Respiratory Syndrome (34.4%), Lassa fever (19.3%) and monkeypox (5.3%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, dengue fever, cholera and measles. The prevalent infectious diseases in Asia were COVID-19 and dengue fever, the prevalent infectious diseases in Africa were COVID-19, Ebola virus disease, cholera, yellow fever, Lassa fever, malaria and measles, the prevalent infectious diseases in America were COVID-19, dengue fever, chikungunya fever and Zika virus disease, the prevalent infectious disease in Europe were COVID-19 and acute hepatitis of unknown aetiology.