Abstract: Quorum-sensing(QS)systems commonly exist in procaryote kingdom and regulate various cellular biological functions, which involves the production and sensing of one or more signal molecules secreted by the members of same species and others, regulation of target genes, expression to coordinate cell behavior in response to cell density. The Gram-negative QS systems were first discovered and extensively characterized in the marine Vibrios. This review focuses on the composition of QS networks in human pathogen Vibrio cholerae; how chemical information is integrated, processed and transduced to control gene expression and how QS interfere with other global regulators.