Abstract: Objective　To evaluate the awareness of knowledge about the Expanded Program on Immunization (EPI), the influence factors and the access to immunization information. Methods　Questionnaire surveys were conducted among the people who took their children to clinic for vaccination. Results　A total of 552 subjects were surveyed, and 516 completed the questionnaires. The awareness rate of basic knowledge about EPI was high (63.18%-97.48%), the awareness rate of professional knowledge about EPI was low (20.16%-62.79%). Significant difference was observed on the awareness rates among the residents with different economic status, education background and occupation (IP/I0.005). Some residents (72.29%) obtained EPI information from EPI doctors, others (59.50%) from immunization certificates. Conclusion　Education background, economic status and occupation were the influence factors on the awareness of the knowledge about EPI, it is necessary to promote the health education about EPI, especially on the professional knowledge about EPI, among different populations.