Abstract: Biosafety in the laboratory for pathogenic microorganism detection is an international hotspot for research. This paper summaries the development and current status of biosafety management of laboratory in China and propose the countermeasures to improve the management system, including laboratory entrance rule; identifying staff's responsibilities in laboratory; conducting training on laboratory biosafety regularly; supervision and inspection on laboratory biosafety regularly and irregularly; further study on laboratory biosafety; strengthening international collaboration to learn the advanced biosafety technology for the laboratory management.