蒋征刚, 陈永弟, 陈恩富, 李倩, 唐学雯, 姚军. 基因工程乙型病毒性肝炎疫苗基础免疫5~11年后抗体阴性儿童加强免疫效果分析[J]. 疾病监测, 2011, 26(9): 679-681.
引用本文: 蒋征刚, 陈永弟, 陈恩富, 李倩, 唐学雯, 姚军. 基因工程乙型病毒性肝炎疫苗基础免疫5~11年后抗体阴性儿童加强免疫效果分析[J]. 疾病监测, 2011, 26(9): 679-681.
JIANG Zheng-gang, CHEN Yong-di, CHEN En-fu, LI Qian, TANG Xue-wen, YAO Jun. Effect of hepatitis B vaccine booster immunization among anti-HBs negative children receiving basic vaccination 5-11 years ago[J]. Disease Surveillance, 2011, 26(9): 679-681.
Citation: JIANG Zheng-gang, CHEN Yong-di, CHEN En-fu, LI Qian, TANG Xue-wen, YAO Jun. Effect of hepatitis B vaccine booster immunization among anti-HBs negative children receiving basic vaccination 5-11 years ago[J]. Disease Surveillance, 2011, 26(9): 679-681.

基因工程乙型病毒性肝炎疫苗基础免疫5~11年后抗体阴性儿童加强免疫效果分析

Effect of hepatitis B vaccine booster immunization among anti-HBs negative children receiving basic vaccination 5-11 years ago

  • 摘要: 目的 评价浙江省儿童基因工程乙型病毒性肝炎(乙肝)疫苗基础免疫后5~11年抗体阴性者不同乙肝疫苗、不同针次加强免疫效果。 方法 2009年9月在浙江省台州市、丽水市、衢州市选择1周岁内完成全程接种乙肝疫苗的5岁以上儿童4407例,采集静脉血,使用化学发光法检测血清乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗-HBs)、乙肝病毒核心抗体(抗-HBc),选择免前三项指标全阴者2164例,按0、1、6完成3针乙肝疫苗接种。第1、3针乙肝疫苗接种后间隔1个月采血,免后检测抗-HBs。 结果 通过对接种第1、3剂次乙肝疫苗后1个月检测抗-HBs,其抗体阳转率大于95%以上,不同疫苗接种3剂次与接种1剂次免疫效果差异有统计学意义。 结论 乙肝疫苗免疫策略实施以来,疫苗免疫效果良好,但抗-HBs阳性率存在随时间推移逐步下降的趋势,建议对5岁以上免疫儿童实施加强免疫会有较好的效果。

     

    Abstract: Objective To evaluate the effect of hepatitis B vaccines booster immunization among the anti-HBs negative children receiving basic vaccination 5-11 years ago in Zhejiang. Methods In September 2009, 4407 children aged >5 years were selected in Taizhou, Lishui and Quzhou in Zhejiang, all of the children completed the basic immunization of hepatitis B within the age 1 year. The blood samples were taken from them to detect HBsAg, anti-HBs and anti-HBc by chemiluminescence immunoassay. Totally 2164 children with negative Results received the booster of hepatitis B vaccine at 0, 1 and 6 months. The blood samples were taken from them one month after the first dose and the third dose to detect anti-HBs. Results The anti-HBs detections at one month after the first and the third doses indicated that the positive conversion rate of the antibodies was >95%. The differences on the immunization effect between the first dose and the third dose of different vaccines were statistical significant. Conclusion Great achievement has been made in hepatitis B immunization since the implementation of hepatitis B vaccination programme, but anti-HBs positive rate could decline as time goes on. It is necessary to conduct booster of hepatitis B vaccine in children aged >5 years.

     

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