Abstract: Objective To analyze the characteristics of the adverse events following immunization (AEFI) in Minhang from 2007 to 2009 reported through suspected adverse events following immunization surveillance system. Methods Descriptive epidemiological analysis was conducted on the surveillance data of AEFI. Results During this period, the average reporting rate of the AEFI was 91.67/lakh in Minhang. AEFI rates of viral, bacterial vaccines and non-vaccine product were 31.75/lakh, 212.04/lakh and 73.40/lakh, respectively. The Reported AEFI rates varied with community, The reported AEFI rate in Longbai street community, where the active surveillance of AEFI started early, was higher than other communities. Most AEFI were low-grade fever and mild local reaction, accounting for 63.47% and 32.18% of the total respectively. The reported rates of fever and local red swelling/induration were 58.03/lakh and 29.42/lakh, respectively. Conclusion The reported AEFI rate in this study was higher than others. It is necessary to explore the model of AEFI active surveillance, improve the sensitivity of vaccine safety surveillance in order to provide more information for safe vaccination.