李洁, 贾蕾, 刘建荣, 李锡太, 张明清, 曲梅, 阎雪, 黎新宇, 黄芳, 王全意. 北京市2010年某幼儿园手足口病聚集疫情的流行病学及病原学特征分析[J]. 疾病监测, 2011, 26(10): 790-793.
引用本文: 李洁, 贾蕾, 刘建荣, 李锡太, 张明清, 曲梅, 阎雪, 黎新宇, 黄芳, 王全意. 北京市2010年某幼儿园手足口病聚集疫情的流行病学及病原学特征分析[J]. 疾病监测, 2011, 26(10): 790-793.
LI Jie, JIA Lei, LIU Jian-rong, LI Xi-tai, ZHANG Ming-qing, QU Mei, YAN Xue, LI Xin-yu, HUANG Fang, WANG Quan-yi. Epidemiological and etiological characteristics of hand foot and mouth disease cluster in a kindergarten in Beijing, 2010[J]. Disease Surveillance, 2011, 26(10): 790-793.
Citation: LI Jie, JIA Lei, LIU Jian-rong, LI Xi-tai, ZHANG Ming-qing, QU Mei, YAN Xue, LI Xin-yu, HUANG Fang, WANG Quan-yi. Epidemiological and etiological characteristics of hand foot and mouth disease cluster in a kindergarten in Beijing, 2010[J]. Disease Surveillance, 2011, 26(10): 790-793.

北京市2010年某幼儿园手足口病聚集疫情的流行病学及病原学特征分析

Epidemiological and etiological characteristics of hand foot and mouth disease cluster in a kindergarten in Beijing, 2010

  • 摘要: 目的 了解2010年北京市某幼儿园手足口病聚集性疫情的流行病学特征及病原学特征。 方法 对本起疫情开展流行病学调查,分析每例患者感染来源,用描述流行病学特征方法进行分析。荧光定量RT-PCR方法检测肠道病毒71型(EV71)和柯萨奇病毒A组16型(Cox A16)。RD细胞进行病毒分离,对病毒分离株的VP1基因序列进行种系发生分析。 结果 某幼儿园某班手足口聚集性疫情7天内共发病6例,罹患率为31.6%,首发病例发病前接触过确诊的手足口患儿。其余患儿发病前和潜伏期的手足口患儿有密切接触。6例患儿中发热4例,占66.7%,在手、足、口腔、臀部均有疱疹,有2例被诊断为重症(构成比为33.3%),均出现脑炎和肺炎等并发症。其中6份咽拭子样本分离出2株EV71毒株(阳性分离率为33.3%)。VP1基因序列分析表明其与北京市2006-2010年EV71分离株核苷酸同源性为94.6%~100.0%。 结论 本起疫情由EV71毒株引起,EV71毒株VP1全长基因序列与北京市2006-2010年分离毒株具有较高同源性,未发生变异。该起疫情提示我们要加强手足口病的健康教育,提高各集体单位关于聚集性传染病的发现和报告能力,提高家长对手足口病的认识程度。

     

    Abstract: Objective To understand the epidemiological and etiological characteristics of hand foot and mouth disease cluster in a kindergarten in Beijing in 2010. Methods Epidemiological survey was carried out to identify the infection source, the descriptive epidemiological analysis was conducted on the incidence data and real-time RT-PCR was performed to detect EV71 and Cox A16. RD cells were used to isolate virus strains. The homogeneity of isolated strains were analyzed. Results Six cases were reported during the outbreak lasting for 7 days, the attack rate was 31.6%. The first case was a contact of hand foot and mouth disease patient. Other cases had close contact with children who suffered from the disease. Four cases (66.7%) had the symptom of fever and developed vesicular exanthema on their mouth, food, hand and buttock. Two severe cases showed the symptom of encephalitis and pneumonia. Two EV71 virus strains were isolated from 6 positive samples. The nucleotide homogeneity of VP1 of these 2 strains with Beijing strains during 2006-2010 was 94.6%-100.0%. Conclusion The hand foot and mouth disease cluster was caused by EV71 which had high homology with the isolated strains in Beijing during 2006-2010. It is necessary to strengthen health education and improve the community's capacity to find and report communicable disease cluster.

     

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