Abstract: To discuss the relationship between HBV, HCV infection and hepatocellular Carcinoma(HCC), understanding the situation of HBV or HCV infection in HCC cases 38 HCC cases and 46 other cancer cases were investigated by detecting the serum markers of HBV and HCV The infection rates of HBV in HCC and other cancer cases were 78.95%(30/38),13.04%(6/46) respectively (χ2=36.90, P<0.01) The distribution of model A (HBsAg+,HBeAg+,HBcAb+), model B(HBsAg+,HBeAb+,HBcAb+) and model C(HBsAg+,HBcAb+) in HCC cas es was 15.79%,28.59% and 26.32%. But the three models were not occurred in other cancer cases,which had significant difference between those two groups.In HCC cases,the rate (55.26%) of HBeAg negative was quite high-er than HBeAb positive,and the rate of HBV, HCV and HBV - HCV mixed infection was 41.18%,11.76%,47.6% respectively.The generation of HCC was closely related with HBV infection.The nifectors of HBV and HBV - HCV mixed infection seemed to have more chance to get HCC,but it did not mean that HCB ivfector was no danger to get HCC.