Abstract: Objective To understand the epidemic characteristics of Hemorrhagic Fever with Renal Syndrome(HFRS)in Guangzhou and to set up the corresponding preventive and cure countermeasures. Methods The investigation data of individual case diagnosed as HFRS in Guangzhou, lab testing results of serum samples of sufferers or suspected sufferers and monitoring results of mouse species, density and toxin-carrying rate of host animals were summarized and assayed. Results The epidemic characteristics of HFRS in Guangzhou were that occurred mainly in a population including young male adults,unemployed indiveduals,workers,the retired and migrant laborere who had a low income;the peak season of onset was focused in win-ter and spring from January to April;the positive detection rate of serological monitoring was 9.8%;the poi-son-carried mouse species were mostly Rattus norvegicus,Suncus murinus,Mus musculus and Rattus flavipec-tus. Conclusion; The morbidity of HFRS in Guangzhou in 2003 had a low-extent increase compared with 2002;the risk of inducing transmission and epidemic had always been present,hence it was necessary to strengthen HFRS related monitoring and prophylactic and control measures to prevent the outburst and epi-demic of HFRS in Guangzhou city.