Abstract: Objective This analysis was to help comprehend the HIV infection status among drug users in Fuzhou City by monitoring SO as to provide basis for implementing preventive and cure counter- measures．Methods Basic condition，behavior and antibodies in serums of drugs users from rehabilita-tion centers were monitored by on-site investigation and serological tests．Results In 2004，9 cases of HIV infection were detected for the first time in 585 drug users，with a detection rate of 1.5％，and ra-tios of venous injection and sharing syringes among drug users were 69．1％and 33．4％ respectively．Conclusion HIV has spread and been transmitted among drugs users in Fuzhou，and given the presence of high—risk behaviors such as sharing syringes and multiple sexual partners，we should take effective measures tO carry Out interventions on related risky behavior in this population．