Abstract: Objective This study was made to understand the behavioral characteristics of drug abusers and their conditions of HIV infection in Yulin city in order to provide a scientific basis for the formulation of interventions．Methods One-to-one questionnaire interviews were conducted by the professionals with unified questionnaires．Intravenous blood samples were taken from the drug abusers for the detection of HIV antibody．Results 102 cases of HIV infection were detect-ed among the 2251 drug abusers surveyed from 2001 tO 2005 with an HIV-positive rate of 4.53％．The HIV-infection rates were highest in Xingye county Fumian district accounting for 16.36％(53/324) and 12.73％(21/165) respectively，with a rate of 8.51％(8/94)among the for-eign resident population．81.61％of the 2251 drug abusers were intravenous drug abusers with needle-sharing occurring in 64.78％ of them．It was found that promiscuity existed iIn 54.95％ of the surveyed (1237/2251)with 71.95％(890/1237)of the promiscuous individuals having never used condoms．99.00％ of the 102 cases of HIV infection were intravenous drug abusers with