Abstract: Objective This paper was designed to explore the ways to construct a monitoring system for symptoms of infectious diseases. Methods The data from the hospital information system (HIS) were integrated into the infectious disease symptom monitoring system through the data mining technology, collated and analyzed. Results The hospital infection symptom monitoring system showed its superiority in fast access and efficiency, making full use of information. Conclusion The hospital infectious disease symptom monitoring system improves the management of infectious diseases in hospital, serving as the cornerstone for general hospitals to fight against sudden public health incidents.