Abstract: Objective 　The study was conducted to investigate the epidemiological characteristics and trends of sexually transmitted diseases(STDs) in Kashgar from 2003 to 2007. Methods　Epidemiological analysis was conducted on the STDs case-report data in Kashgar from 2003 to 2007 by using Epi Info and STDs Database Management System. Results　A total of 11 144 STDs cases were reported during the past five years with the average annual incidence of 60.57/lakh. The STDs incidence increased from 40.41/lakh in 2003 to 88.04/lakh in 2007. Conclusion　The incidence of STDs increased annually, significant change appeared in the constituent ratio of disease species with syphilis accounted for the largest part, and the reported number of HIV infection cases increased considerable each year, though the gender difference was not significant.