Abstract: ObjectiveTo determine the flora of epidemic cerebrospinal meningitis (ECM) and human antibody levels against ECM in Liaoning province. MethodsECM bacteria were cultured and identified on chocolate agar plates under (36 0.5) ℃ with 5% COsub2/sub, antibodies detected by ELISA. ResultsIn Liaoning province, most meningitis cases were caused by group A meningococci, and the rest group C. Group A meningococci were primarily detected among carriers, accounting for 72%. The protective rate of antibodies against group A meningococci was 76.25%, the mean antibody content 11.78 g/ml. The protective rate of Group C antibodies was 53.39%, the mean antibody content 3.73 g/ml. Great differences were noticed in between Group A and C antibody levels. Significant differences were found in the antibody levels between age groups. ConclusionInfants and children were primarily affected by meningitis in Liaoning province. However, the susceptible age is increasing, suggesting potential flora variation. Since current human antibody levels are not sufficient to prevent the epidemic of group C meningitis, is it necessary to strengthen the immunity in general population and improve disease surveillance and countermeasures to prevent and control ECM epidemic.