Abstract: Objective To explore related influencing factors on drug users compliancy to methadone maintenance treatment (MMT) and provide evidence to improve their compliancy to MMT. Methods In December 2010, the questionnaire survey was conducted among 962 drug users receiving MMT in Yueqing, Yongjia and Cangnan counties in Wenzhou and multivariate logistic regression analysis was conducted to understand the influencing factors on their compliancy to MMT. Results The analysis indicated that the adverse reaction of treatment, weak willing of participants, unsatisfied attitude of medical workers, receiving no education about AIDS and unimproved life quality after reviving MMT were the negative factors on the MMT compliancy with the OR value of 46.53, 2.91, 3.35, 2.08 and 2.53 respectively (P0.05), drug unavailability during the treatment was the positive factor. In addition, the differences on the marital status, economic income, family members attitude to MMT, contact with people who didnt use drug, treatment dosage, negative emotion, MMT clinics location and service time of the clinics between the drug users who continued treatment or stopped treatment had statistical significance (P0.05). Conclusion It is essential to improve the MMT clinic service in both intervention skill and service attitude to increase drug users compliancy to MMT for the purpose of AIDS prevention and control.