Abstract: Objective To understand the epidemiological characteristics of pertussis in Xinjiang from 2004 to 2012, and provide scientific evidence for developing pertussis immunization strategies and prevention/control measures. Methods Descriptive epidemiological analysis was conducted on the incidence data of pertussis in Xinjiang from 2004 to 2012 collected from the Disease Reporting Information System. Results A total of 3760 pertussis cases, including 5 deaths, were reported during this period. The average annual incidence was 2.02/lakh. Most cases were children aged 0-15 years, accounting for 99.36% of the total. The incidence in children aged 0-4 years was highest, and the average annual incidence in this age group was 28.46/lakh from 2010 to 2012. The southern region had more pertussis cases reported than in northern region, accounting for 73.75% of the total. Conclusion The incidence of pertussis was still very high in Xinjiang. It is necessary to strengthen the surveillance of pertussis and improve pertussis immunization.