Abstract: Dengue fever mainly occurs in tropical and subtropical regions, and helminths, such as clonorchis sinensis, pinworm, hookworm, ascaris, are common in these regions. It is believed that the co-infection of worms and dengue virus might increase in the risk of dengue hemorrhagic fever or dengue shock syndrome. This paper summarizes the progress in the research of dengue fever immunization mechanism and helminthic infection immunization mechanism to study whether there is correlation between co-infection of dengue virus and common helminths and related immunization mechanism and provided information for related research.