Abstract:
With the development of molecular biology, genomics and bioinformatics, the molecular epidemiology of
Leptospira has been further studied. New molecular typing methods and the sequencing of a large number of
Leptospira genomes have enabled researchers to gain a new understanding of
Leptospira. Based on the molecular classification methods of
Leptospira applied at home and abroad in recent years, this paper summarizes the 16S rRNA genotyping, pulsed field gel electrophoresis, site sequence classification, site variable number tandem repeat sequence classification and whole genome sequencing to help the finding of new type strains of
Leptospira, and revealing the host and regional transmission relationship among different strains. This review can provide reference for the application of molecular typing methods and the prevention and control of leptospirosis in the future.