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Du Chunhong, Wang Peng, Yang Shan, He Lichun, Chen Chaonian, Liang Yun, Wang Anwei, Gao Zihou. Detection of virulence of Pasteurella multocida isolates from wild rodents in Yunnan[J]. Disease Surveillance, 2022, 37(2): 198-201. DOI: 10.3784/jbjc.202103240153
Citation: Du Chunhong, Wang Peng, Yang Shan, He Lichun, Chen Chaonian, Liang Yun, Wang Anwei, Gao Zihou. Detection of virulence of Pasteurella multocida isolates from wild rodents in Yunnan[J]. Disease Surveillance, 2022, 37(2): 198-201. DOI: 10.3784/jbjc.202103240153
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Detection of virulence of Pasteurella multocida isolates from wild rodents in Yunnan

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    • Abstract
  •   Objective  To understand the virulence of Pasteurella multocida isolates from the wild rodents in a rodent epidemic in Simao of Yunnan province in 2016.
      Methods  Two strains of P. multocida were isolated from dead wild rodents, which belonged to serotype A and F by molecular typing. Balb/C mice were inoculated with the two strains and their mixture (1∶1) by routine challenge test, and the median lethal dose (LD50) of each group was calculated.
      Results  The LD50 of P. multocida serotype A, serotype F strains and their mixture to Balb/C mice were 1.1×102, 5.0×106 and 5.8×102. By statistical analysis, the virulence of serotype A strain was strongest, and the virulence of serotype F strain was lower than that of serotype A strain and the mixture.
      Conclusion  P. multocida serogroup A and F strains isolated in this rodent epidemic had strong virulence to Balb/C mice, especially serotype A strain, belonging to very virulent P. multocida.
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