Ten-year recurrence rate in pulmonary tuberculosis patients after successful treatment and influencing factors in Fujian

  Objective  To analyze the 10-year recurrence in pulmonary tuberculosis (TB) patients after successful treatment in Fujian province and provide evidence for TB prevention and control.

  Methods  The data of pulmonary TB patients during 2010–2020 in Fujian were collected from China Disease Prevention and Control Information System. The 10-year recurrence rate were calculated, and the influencing factors were analyzed by a Cox proportional hazard regression model.

  Results  Among the 18 367 cured pulmonary TB patients surveyed in Fujian, 219 relapsed within 10 years. The recurrence rate was 0.12/100 person-years and the median of recurrence interval was 47.40 months. Multivariate Cox proportional hazard regression analysis showed that being male (Hazard ratio, HR=1.87, 95% CI: 1.31–2.68), local registered residence (HR=1.60, 95% CI: 1.07–2.39), medical care seeking delay >14 days (HR=1.37, 95% CI: 1.03–1.82), first diagnosis in special TB hospital and other hospital (HR=3.06, 95% CI: 2.13–4.39; HR=1.66, 95% CI: 1.09–2.53), retreatment (HR=1.76, 95% CI: 1.17–2.65) were the major risk factors for the recurrence in the cured pulmonary TB patients.

  Conclusion  The 10-year recurrence rate of pulmonary TB patients was 0.12/100 person-years in Fujian. Cured TB patients who were male, local residents, smear-positive, retreated patients and had medical care seeking delay >14 days and first diagnosis in special TB hospital or other hospital had higher risk for recurrence.