Drug sensitivity of 105 clinical isolates of Mycobacterium abscessus to 10 antibacterial drugs

  Objective   To analyze the drug sensitivity of clinical isolates of Mycobacterium abscessus (M. abscessus) to 10 kinds of antibiotics and to provide reference for the treatment of M. abscessus disease.

  Methods  Clinical strains of M. abscessus isolated and identified in Hunan Chest Hospital from 2019 to 2020 were collected and microporous drug-sensitive plate minimum inhibitory concentration (MIC) test was performed for detecting the susceptibility of M. abscessus to 10 antibiotics including Sulfamethoxazole, Linezolid, Ciprofloxacin, Imipenem, Moxifloxacin, Cefoxitin, Amikacin, Clarithromycin, Tobramycin and Doxycycline (Doxycycline).

  Results   A total of 105 clinical isolates of M. abscessus were collected. The results showed that M. abscessus was high sensitivity to Amikacin and Clarithromycin, accounted for 98.10% and 93.33% respectively. The sensitivity of M. abscessus to linezolid was 78.10%, while the sensitivity of the other drugs was less than 50%. M. abscessus had the strongest resistance to Doxycycline, of which the resistance rate was 84.76%. The drug resistance rates of Sulfamethoxazole, Ciprofloxacin and Imipenem were also high, which were 75.24%, 74.28% and 72.38%, respectively. 96.19% (101/105) of the strains were resistant to multiple antibiotics simultaneously.

  Conclusion   M. abscessus has a high rate of resistance to antibiotics. Amikacin, Clarithromycin and Linezolid can be used as the best antibiotics for clinical treatment of M. abscessus disease. It is best to carry out precise anti-infection treatment under sensitivity test.