风湿免疫病合并结核病研究进展

Progress in research of rheumatic immune disease complicated with tuberculosis

  • 摘要: 风湿免疫病与结核病都是需要长期治疗和持续管理的慢性疾病。 由于风湿免疫病患者自身免疫功能异常,并可能接受皮质类固醇、抗肿瘤坏死因子抑制剂等药物的治疗,其比一般人群更易感染结核分枝杆菌乃至发展为活动性结核病。 本研究综合分析了风湿免疫病合并结核病的疫情流行现况、影响因素、预防控制策略、筛查方案及防治工作面临的挑战等方面,并提出进一步开展具有全国代表性的疾病负担调查研究,加强科室联合协作,推进更为普适的风湿免疫病患者结核病筛查方案,加强卫生服务资源的可及性,降低患者的医疗费用负担等强化风湿免疫病合并结核病防控工作的政策建议,以期为制定更有效的风湿免疫病合并结核病的防控策略和政策措施提供参考依据。

     

    Abstract: Rheumatic immune disease and tuberculosis (TB) are both chronic diseases that require long-term treatment and continuous management. Because patients with rheumatic immune disease have abnormal autoimmune functions and may receive treatment with drugs such as corticosteroids and anti-tumor necrosis factor inhibitors, they are more likely to be infected with Mycobacterium tuberculosis and even suffer from active TB compared with general population. This study comprehensively analyzes the prevalence of rheumatic immune disease complicated with TB, influencing factors, prevention and control strategies, screening programs and challenges in the prevention and control, and suggests improvement focus to strengthen the prevention and control of rheumatic immune disease complicated with TB, including disease burden survey and research at national level, collaboration among departments, screening for TB in rheumatic immune disease patients, accessibility of health service resources, and the medical cost burden of patients, to provide reference for the development of more effective strategies and policies to prevent and control rheumatic immune disease complicated with TB.

     

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