Abstract:
Objective To review the clinical characteristics, laboratory testing, and treatment process of 2 patients with psittacosis, providing a reference for the early diagnosis, rational drug use, and regional prevention and control of psittacosis in respiratory syndrome cases in Jinzhong city, Shanxi province.
Methods Two cases of Chlamydia psittaci positive samples detected in sputum specimens of respiratory syndrome in 2024 were analyzed by multiplex PCR and metagenomic next-generation sequencing (mNGS) Corresponding clinical data of the cases were collected for case reports.
Results Both patients mainly presented with fever, cough and nausea. Both patients tested positive for Chlamydia psittaci by multiplex PCR (Ct values: 27.19 and 31.11, respectively), and specific Chlamydia psittaci sequences were detected by mNGS (case 1: 41 sequences; case 2: 30 sequences). Case 1 was discharged 19 days after moxifloxacin treatment, and case 2 was discharged 6 days after doxycycline tablets treatment.
Conclusion Clinical manifestations of Chlamydia psittaci pneumonia are non-specific. The history of bird contact can be traced by inquiry combined with local migratory bird migration characteristics. Multiplex PCR can quickly screen pathogens, and mNGS can accurately identify pathogens. Hierarchical selection of detection technologies can be made according to actual conditions. Tetracycline drugs have better therapeutic effect than quinolones, but this conclusion is based on small-sample observation and needs verification by large-sample clinical studies.
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