144株鸟分枝杆菌和20株胞内分枝杆菌对15种药物的敏感性分析

杭昊; 李马超; 刘海灿; 李桂莲; 赵秀芹; 万康林; 赵丽丽

doi:10.3784/jbjc.202601300070

144株鸟分枝杆菌和20株胞内分枝杆菌对15种药物的敏感性分析

Analysis on susceptibility of 144 clinical strains of Mycobacterium avium and 20 clinical strains of Mycobacterium intracellulare to 15 antibiotics

摘要

摘要:
目的分析鸟分枝杆菌和胞内分枝杆菌菌株对15种药物的敏感性特征及两种菌间的药物敏感性差异，为鸟分枝杆菌和胞内分枝杆菌感染的耐药监测和治疗提供参考依据。
方法采用微量肉汤稀释法检测144株鸟分枝杆菌和20株胞内分枝杆菌临床分离菌株对克拉霉素、阿米卡星、莫西沙星、利福布丁等15种药物的敏感性，分析临床分离菌株对药物的敏感性，比较交叉耐药性及两菌种间的敏感性差异。
结果鸟分枝杆菌敏感率较高的药物有阿米卡星（97.92%，141/144）、妥布霉素（97.92%，141/144）、利福布丁（97.92%，141/144）和克拉霉素（95.83%，138/144）；胞内分枝杆菌敏感率较高的药物有阿米卡星（100.00%，20/20）、妥布霉素（100.00%，20/20）、利福布丁（100.00%，20/20）、克拉霉素（100.00%，20/20）、链霉素（100.00%，20/20）和氯法齐明（100.00%，20/20）。胞内分枝杆菌对替加环素和利福平的敏感性显著高于鸟分枝杆菌（χ²=4.983、6.267，P=0.026、0.012）。
结论鸟分枝杆菌和胞内分枝杆菌均对阿米卡星、妥布霉素、利福布丁、克拉霉素和链霉素具有较好的敏感性。对两种菌的药敏特征分析可为临床鸟分枝杆菌和胞内分枝杆菌感染治疗提供用药物参考。

Abstract:
Objective To analyze the drug susceptibility of Mycobacterium avium and Mycobacterium intracellulare strains to 15 antibiotics, compare the difference in drug susceptibility between the two species and provide reference for drug resistance surveillance and treatment of M. avium and M. intracellulare infections.
Methods Broth microdilution method was used to analyze the susceptibilities of 144 clinical isolates of M. avium and 20 clinical isolates of M. intracellulare to 15 antibiotics, including clarithromycin, amikacin, moxifloxacin, and rifabutin, and the differences in cross-resistance and drug susceptibility between the two species were compared.
Results M. avium was highly sensitive to amikacin (97.92%, 141/144), tobramycin (97.92%, 141/144), rifabutin (97.92%, 141/144), and clarithromycin (95.83%, 141/144). M. intracellulare was highly sensitive to amikacin (100.00%, 20/20), tobramycin (100.00%, 20/20), rifabutin (100.00%, 20/20), clarithromycin (100.00%, 20/20), streptomycin (100.00%, 20/20), and clofazimine (100.00%, 20/20). M. intracellulare showed significantly higher sensitivity to tigecycline and rifampicin compared with M. avium （χ²=4.983、6.267, P=0.026、0.012）.
Conclusion Both M. avium and M. intracellulare were all sensitive to amikacin, tobramycin, rifabutin, clarithromycin and streptomycin. The analysis on the drug susceptibility of the two species can provide reference for the antibiotic selection in the clinical treatment of M. avium and M. intracellulare infections.

HTML全文

参考文献(29)

施引文献

资源附件(0)