2015-2024年云南省0~14岁儿童肺结核流行病学特征分析

Analysis on epidemiological characteristics of pulmonary tuberculosis in children aged 0−14 years in Yunnan, 2015−2024

  • 摘要:
    目的 分析2015-2024年云南省0~14岁儿童肺结核报告发病情况及流行特征,为制定儿童结核病防控策略提供依据。
    方法 通过中国疾病预防控制信息系统中的传染病监测系统,2015-2024年收集云南省0~14岁儿童肺结核患者信息,使用SPSS Statistics 19.0软件、Joinpoint 5.0.1软件分析疾病的流行趋势、三间分布、病原学检查等情况。
    结果 2015-2024年云南省0~14岁儿童肺结核年均报告发病率为5.24/10万,总体趋于稳定,差异无统计学意义(P>0.05),年报告发病率趋势呈阶段性变化,由2015年的4.77/10万上升至2019年的6.62/10万年度变化百分比(APC)=11.24%,95%置信区间(CI):1.68%~49.02%,P<0.05,此后下降至2024年的4.11/10万(APC=−8.63%,95%CI:−31.80%~−2.43%,P<0.05)。0~14岁儿童肺结核病原学阳性率低于全人群水平,呈上升趋势(趋势χ2=212.015,P<0.001);报告发病率与全人群呈高度正相关(r=0.842,P<0.001)。
    结论 2015-2024年云南省0~14岁儿童肺结核报告发病率处于较低水平,整体趋势较为稳定;相较于成人肺结核,儿童结核病病原学阳性率显著偏低,地区分布与全人群报告发病率高度相关,提示应加强对儿童结核潜伏感染者的预防性干预。

     

    Abstract:
    Objective To analyze the reported incidence and epidemiological characteristics of pulmonary tuberculosis (TB) in children aged 0−14 years in Yunnan province from 2015 to 2024 and provide evidence for the development of the strategies for the prevention and control of pulmonary TB in children.
    Methods Through the infectious disease surveillance system in China’s Disease Prevention and Control Information System, the incidence data of pulmonary TB in children aged 0−14 years in Yunnan from 2015 to 2024 were collected, and software SPSS Statistics 19.0 and Joinpoint 5.0.1 were used to analyze trends in the prevalence, spatial, time and population distributions, and results of pathogen testing of pulmonary TB.
    Results From 2015 to 2024, the annual reported incidence of pulmonary TB in children aged 0−14 years was 5.24/ 100000 in Yunnan, with a generally stable trend; the differences had no significance (P>0.05). The annual incidence showed periodic changes, increasing from 4.77/100000 in 2015 to 6.62/100000 in 2019 annual percentage change (APC)=11.24%, 95% Confidence Interval (CI): 1.68%–49.02%, P<0.05, and decreasing to 4.11/100000 in 2024 (APC=−8.63%, 95%CI: −31.80%–−2.43%, P<0.05). The proportion of 0−14 years old children with positive test results of the causative agent of pulmonary TB was lower than that in general population, but the proportion showed an upward trend (trend χ2=212.015, P<0.001); the reported incidence of was highly correlated with that in general population (r=0.842, P<0.001).
    Conclusion From 2015 to 2024, the reported incidence of pulmonary TB in children aged 0−14 years remained at low level in Yunnan, with a relatively stable trend over time. Compared with adults, the rate of positive results for the causative agents of pulmonary TB in children was significantly lower. The area distribution of the disease was closely related to the overall incidence rate in general population, suggesting the need for enhanced preventive measures targeting children with latent TB.

     

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