Abstract: This study focuses on the practical application of technology for the prevention and control of respiratory infectious diseases in core megacities by analyzing the current status of key prevention and control technologies and construction of the oolkit with core modules of prevention and control preparation, multi-channel surveillance, risk assessment, prediction and early warning, emergency response and public health education. The main contents and key technologies of these modules are further improved for the purpose of “prevention and control, surveillance, evaluation, early warning, response and health education”to provide technical references for the early detection, rapid assessment, accurate early warning and timely response in respiratory infectious disease outbreaks and improve the accuracy and intelligence level of the prevention and control of respiratory infectious diseases in core megacities.