Abstract:
Objective To evaluate the association between body roundness index (BRI) and all-cause mortality in diabetes patients.
Methods Data of 2 914 previous diagnosed or screen-diagnosed diabetes patients in China Kadoorie Biobank (CKB) study in Tongxiang, Zhejiang province were used. After excluding 65 diabetes patients with cancers, stroke, and heart disease at baseline study, a total of 2 812 diabetes patients aged 30-79 years were included in the final analysis. The diabetes patients were divided into 4 groups according to their quartiles of BRI. Cox regression models were used to estimate the hazards ratios (HR) for the associations of baseline BRI with all-cause mortality. Restricted cubic spline was used to analyze the dose-response relationship between BRI and all-cause mortality.
Results The mean age of the diabetes patients was 56.24±9.30 years. The BRI was 3.59±1.16. In 30 232 person-years of the follow-up (median 11.28 years) for the diabetes patients, a total of 185 men and 248 women died. Compared with the diabetes patients with the lowest BRI (<2.77), after adjusting for socio-demographic factors, lifestyle, and BMI, the HRs of all-cause mortality in the diabetes patients with BRI 2.77−3.49, 3.50−4.28, and ≥4.29 were 1.16 (95%CI: 0.85−1.58), 1.37 (95%CI: 0.96−1.94), and 2.26 (95%CI: 1.47−3.48), respectively (Wald χ2=12.836, P<0.001). Restricted cubic spline model showed an approximate J-shaped relationship between BRI and all-cause mortality.
Conclusion High BRI might be associated with increased risk for all-cause mortality in adults with diabetes.
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