Abstract: 218 strains of Neisseria meningitidis(Nm)serogroup A，B and C were collected from 21 provinces of China in 1966～1993．their sensitivity to 7 routine antibiotics were determined by us-ing the method of improved Kirby-Bauer and agar dilution．On 108 strains of serogroup A Nmtested．20 strains were discovered to be resistant to SNZ，(of which 13 strains were isolated from patients and 7 stains frombaeterium carriers)．31 strains resisted ASP．In 101 strains of serogroup B Nm．40 straino resisted SNZsupr/sup．(of which 26 strains isolated from patients and 14 straino from bacterium carriers);17 strains resisted ASP and 10 strains resisted CF．In 9 strains of serogroup CNm．5 strains resisted SMZsupr/sup；2 strains resisted ASP．We did not discovered the risistant Chl straim 0f Nm．The resuts showed that we should strengthen the surveillance on the antibiotic sensitivity 0f Nm in the control of epidemic meningitis．