Objective This study was designed to find out how to make good use of network information resources and to control infectious disease outbreaks with monitoring and early warning. Methods Using National Electronic Disease Surveillance System to output cards and screen for clustered cases, and statistically analyze its effect on reducing disease outbreaks with SPSS 11.5 software. Results Monitoring from January to September 2006, there were 77 reports of clustered cases in all, and with site management,65 reports were controlled without any new incidence. There were 8 reports which did report or seek medical care after site investigation, and the incidences increased to outbreaks, and they were treated as outbreaks. There were 4 reports which were not properly controlled with site managements and developed into outbreaks. In all, there were 4o reports of outbreaks, with 1145 cases, and the outbreak cases is 9.91% of all the cases during this period of time (11 552 cases).In 2005, there were there were 83 reports of outbreaks, with 1831 cases, and the outbreak cases is 16.46% of all the cases during that period of time (11 125 cases).Compared with 2005, the outbreak rate in 2006 dropped 41.87%(x2=213.044.P0.01). Conclusion Network monitoring and early warning of outbreaks of infectious diseases can foresee the trends of the diseases, and with effective site measures, the outbreaks can be reduced, which is of significant importance to the control of infectious diseases.