Abstract: Objective This study was conducted to gain insight into the germ-carrying situation, bacterial distribution,drug resistance and immune antibody level of epidemic cerebrospinal meningitis (ECM)in Wenzhou,Zhejiang for effective prevention of ECM.Methods Lucheng and Ouhai were chosen as the monitoring sites according to the ECM monitoring program.Pharynx swab samples col- lected from healthy people of different ages were inoculated to the double-anti-chocolate-colored blood agaragar for the isolating culture,identification and antimicrobial susceptibility test for Neisseria Meningitidis(Nm).Collected sera were detected the serogroup A and C specific IgG antibody by ELISA.Results One case of serogroup C(male,20 years old)was detected.The Nm carder rate a- mong healthy crowd was 2.98%(10/336);the positive rate of serogroup A antibody among healthy crowd 47.09%(81/172)and serogroup C antibody 35.47%(61/172).Conclusion The incidence rate of epidemic cerebrospinal meningitis and the Nm carrier rate were low.Most people had high immunity to the A group of epidemic cerebrospinal meningitis albeit low to the C group.It is necessary to strengthen the vaccination of A+C group of epidemic cerebrospinal meningitis with close attention paid to the colony diversification and the alteration of resistant swains of different serums groups.