49株脑膜炎奈瑟菌体外抗菌药物敏感性检测

李马超 徐丽 黄鑫 高源 李艺星 尹尊栋 李军宏 邵祝军

李马超, 徐丽, 黄鑫, 高源, 李艺星, 尹尊栋, 李军宏, 邵祝军. 49株脑膜炎奈瑟菌体外抗菌药物敏感性检测[J]. 疾病监测, 2008, 23(2): 76-79. doi: 10.3784/j.issn.1003-9961.2008.2.76
引用本文: 李马超, 徐丽, 黄鑫, 高源, 李艺星, 尹尊栋, 李军宏, 邵祝军. 49株脑膜炎奈瑟菌体外抗菌药物敏感性检测[J]. 疾病监测, 2008, 23(2): 76-79. doi: 10.3784/j.issn.1003-9961.2008.2.76
LI Ma-chao, XU Li, HUANG Xin, GAO Yuan, LI Yi-xing, YEN Zun-dong, LI Jun-hong, SHAO Zhu-jun . Drug susceptibility testing in vitro of 49 strains of Neisseria meningitides[J]. Disease Surveillance, 2008, 23(2): 76-79. doi: 10.3784/j.issn.1003-9961.2008.2.76
Citation: LI Ma-chao, XU Li, HUANG Xin, GAO Yuan, LI Yi-xing, YEN Zun-dong, LI Jun-hong, SHAO Zhu-jun . Drug susceptibility testing in vitro of 49 strains of Neisseria meningitides[J]. Disease Surveillance, 2008, 23(2): 76-79. doi: 10.3784/j.issn.1003-9961.2008.2.76

49株脑膜炎奈瑟菌体外抗菌药物敏感性检测

doi: 10.3784/j.issn.1003-9961.2008.2.76

Drug susceptibility testing in vitro of 49 strains of Neisseria meningitides

  • 摘要: 目的 了解2005-2006年中国脑膜奈瑟菌分离株(Neisseria meningitides,Nm)的抗菌药物敏感性变化趋势,为选择抗菌药物对流行性脑脊髓膜炎(流脑)患者进行治疗提供参考.方法 采用肉汤稀释检测最低抑菌浓度(MICs)方法、药敏纸片扩散(K-)法和E-test试纸条检测方法对本实验室收集的49株(16株A群、33株C群)2005-2006年分离的患者Nm菌株进行体外抗菌药物敏感性检测.结果 16株A群Nm菌株对复方新诺明、四环素、左氧氟沙星、萘啶酸4种抗菌药物耐药,对环丙沙星耐药或中度敏感.33株C群Nm菌株对复方新诺明耐药,31株(93.9%)C群菌株对萘啶酸耐 药,20株(60.6%)C群菌株对左氧氟沙星耐药,17株(51.5%)C群菌株对环丙沙星耐药.分别发现对青霉素不敏感的4株A群和1株C群Nm菌株.结论 2005-2006年,中国的A群和C群Nm菌株对磺胺类药物和喹诺酮类药物普遍耐药,此两类药物不适合中国流脑的临床用药及人群预防性给药.K-药敏纸片和肉汤稀释MICs及E-test方法具有较高的一致性.
  • [1]Hu XJ,Li XW,Ji YD.The epidemic investigation of epidemic cere-bropinal meningitis in China[J].Chin J Epidemiol Dec,1991,12(3):136-139.(in Chinese)胡绪敬,李新武,计银铎.中国流行性脑脊髓膜炎流行病学研究(流脑专辑)[J].中华流行病学杂志,1991,12(3):136-139. [2]Shao ZJ,Li W,Ren J,et al.Identification of a new Neisseria,meningitidis serogroup C clone from Anhui province,China[J].Lancet,2006,367(9508):419-423. [3]Xu L,Shao ZJ,Li MC,et al.Test on susceptibility of Neisseria meningitidis to 12 antimicrobial agents.Chinese Journal of Vaccines andImmunization,2006,12(1):53-55.徐丽,邵祝军,李马超,等.脑膜炎奈瑟菌对12种抗菌药物体外敏感性榆测[J].中国计划免疫,2006,12(1):53-55. [4]CLIS.Performance standards for antimicrobial susceptibility testing sixteenth informational supplement[J].CLIS,2006,26(3):71-72. [5]General Administration Quality and Technical Supervision of the People's Republic of China.The diagnose standard and dispose pfinciple of epidemic cerebrespinal meningitis (GB 168842-1997).国家技术监督局.流行性脑脊髓膜炎诊断标准及处理原则(GB 168842-1997). [6]Brunen A,Peetermans W,Verhaegen J,et al Meningitis due to Neisseria meningitidis with intermediate susceptibility to penicillin[J].Eur J Clin Microbiol Infect Dis,1993,12:969-970. [7]Hansman D,wati S Lawrence A,et al.Have South Australian isolates of Neisseria meningitidis become less susceptible to penicillin,ri fampicin and other drugs A study of strains isolated over three decades,1971-1999[J].Pathology,2004,36:160-165. [8]Latorre C,Gené A,Juncesa T,et al.Neisseria nveningitidis:evolution of penicillin resistance and phenotype in a children's hospital in Barcelona,Spain[J].Aeta Pacdiatr,2000,89:661-665. [9]Quagliarello VJ,Scheld WM.Treatment of bacterial meningitis[J].N Engl J Med,1997,336:708-716. [10]Sutcliffe EM,Jones DM.Penicillin-insensitive meningoeocci in theUK[J].Lancet,1998:657-658. [11]NCCLS.Approved standard M7-A6.Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically[S].Wayne.Pa:NCCLS.2003.
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出版历程
  • 收稿日期:  2007-07-11
  • 刊出日期:  2008-02-29

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