目的 调查太原市分离的志贺菌菌株的主要血清型和对常用抗菌药物的耐药性.方法 对从腹泻患者分离的志贺菌菌株进行血清分型、生化鉴定和药物敏感试验.结果 129份腹泻样本分离出阳性菌株40株,其中福氏志贺菌33株,占分离菌株的82.5%,宋内志贺菌7株,占分离总数的17.5%;福氏志贺菌中,4c 型21株,占63.6%.福氏志贺菌对萘啶酸100%耐药,对氨苄西林、四环素耐药性均为97%,对头孢噻肟、庆大霉素的药物敏感性均为97%.宋内志贺菌对萘啶酸、四环素、复方新诺明均100%耐药;对阿莫西林、头孢噻肟、环丙沙星的敏感性均为100%.结论 2006年太原市志贺菌优势菌型为福氏志贺菌4c型,志贺菌不同血清型对几种常用抗菌药物出现不同程度的耐药性.
Objective The study was conducted to investigate the main serotypes and drug resistance to commonly used antibiotics of isolated Shigella strains in Taiyuan. Methods Serotyping, biochemical identification and drug susceptibility tests were performed for the Shigella strains isolated from diarrhea patients. Results There were 40 positive strains isolated from 129 diarrhea samples, including 33 strains of Shigella flexneri, accounting for 82.5% of all isolates; 7 strains of Shigella sonnei, accounting for 17.5%. 21 strains of Shigella flexneri type 4c were found, accounting for 63.6% of all shigella flexneri strains. The Shigella flexneri strains had 100% resistance to nalidixic acid, and 97% resistance to ampicillin and tetracycline. By contrast, they had 97% sensitivity to cefotaxime and gentamicin. The Shigella sonnei strains had 100% resistance to nalixidic acid, tetracycline and co-trimoxazole, 100% sensitivity to amoxicillin, cefotaxime and ciprofloxacin. Conclusion The predominant Shigella strain was Shigella flexneri type 4c in Taiyuan in 2006. Different serotypes of Shigella presented varying degrees of resistance to commonly used antibiotics.