枸橼酸杆菌对β-内酰胺类抗生素的耐药机制

余燕 徐建国 熊衍文 叶长芸

引用本文: 余燕, 徐建国, 熊衍文, 叶长芸. 枸橼酸杆菌对β-内酰胺类抗生素的耐药机制[J]. 疾病监测, 2008, 23(3): 180-182. DOI: 10.3784/j.issn.1003-9961.2008.3.180 shu
Citation:  YU Yan, XU Jian-guo, XIONG Yan-wen and YE Chang-yun . Mechanism of resistance to β-lactam antibiotics in Citrobacter[J]. Disease Surveillance, 2008, 23(3): 180-182. DOI: 10.3784/j.issn.1003-9961.2008.3.180 shu

枸橼酸杆菌对β-内酰胺类抗生素的耐药机制

摘要: 枸橼酸杆菌(Citrobacter)是一种条件致病菌,近年来在临床上造成的感染越来越多,随之而来的是枸橼酸杆菌对常用抗生素(如-内酰胺类、氨基糖甙类和喹诺酮类等药物)的耐药性日益突出.枸橼酸杆菌对-内酰胺类抗生素的耐药机制主要是产生特异性的-内酰胺酶,而且不同种枸橼酸杆菌对抗生素的敏感性不同.因此,了解枸橼酸杆菌的耐药机制及进展,对预防和治疗由该属细菌引起的感染以及控制耐药性的蔓延有重要意义.

English

    1. [1]Zhang XB,Fu WL,Liao Y,et al.Identification,antibacterial snsceptibility and gene typing of clinical ESBLs-producing bacteria[J].Chin J Nosocomiol,2005,15(4):386-389.(in Chinese)张晓兵,府伟灵,廖扬,等.临床产ESBLs细菌的耐药特征和基因分型的研究[J].中华医院感染学杂志,2005,15(4):386-389. [2]Kim J,Yu M.Prevalence of Derepressed AmpC Mutants and Extended-Spectrum-Lactamase Producers among Clinical Isolates of Citrobacter freundii,Enterobacter spp.,and Serratia marcescens in Korea:Dissemination of CTX-M-3,TEM-52,and SHV-12[J].Clin Microbiol,2005,43(5):2452-2455. [3]Yang QW,Xu YC.Detection of inducible and constitutive AmpC and Treatment of the infections by strains producing AmpC[J].Chin J Lab Med,2005,28(4):457-460.(in Chinese)杨启文,徐英春.诱导型AmpC酶和结构型酶的检测与产酶菌株感染的治疗进展[J].中华检验医学杂志,2005,28(4):457-460. [4]Ryuichi N,Ryoichi O,Nakano Y,et al.CFE-1,a Novel Plasmid-Encoded AmpC β-Lactamase with an ampR Gene Originating from Citrobacter freundii[J].Antimicrob Agents Chemother,2004,8(4):1151-1158. [5]Sanguinetti M,Posteraro B.Characterization of clinical isolates of enterobacteriaceae from Italy by the BD Phoenix.extended-spectrum beta-lactamase detection method[J].Clin Microbiol,2003,41(4):1463-1468. [6]Baha A,Johann D,Ellen S,et al.Community-Onset Disease Caused by Citrobacter freundii Producing a Novel CTX-M β-Lactamase,CTX-M-30,in Canada[J].Antimierob Agents Chemother,2004,48(11):4435-4437. [7]Perilli M,Luzzaro F.Novel TEM-type extended-spectrum beta-lactamase.TEM-134 in a Citrobacter Koseri clinical isolate[J].Antimicrob Agents Chemother,2005,49(4):1564-1560. [8]Muta T,Tsuruta N,Seki Y,et al.A nococomial outbreak due to novel CTX-M-2-producing strains of Citrobacter koseri in a hematoogical ward[J].Jpn J Infect Dis,2006,59(1):69-71. [9]Ruppe E,Bidet P,Verdet G,et al.First Detection of the Ambler Class C 1 AmpC-Lactamase in Citrobacter freundii by a New,Simple Double-Disk Synergy Test[J].Clin Microbiol,2006,41(11):4204-4207. [10]Brenner D,O'Hara C,Grimont P,et al.Biochemical identification of Citrobacter species defined by DNA hybridization and deseription of Citrobacter gillenii sp.nov.(formerly Citrobacter genomospecies 10) and Citrobacter murliniae sp.nov.(formerly Citrobacter genomospecies 11).[J].Clin Microbiol,1999,37(8):2619-2624. [11]Petrella S,Renard M,Ziental-Gelus N,et al.Characterization of the chromosomal class A beta-lactamase CKO from Citrobacter koseri[J].FEMS Microbiol.Lett,2006,254(7):285-292. [12]Underwocd S,Avison M.Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology[J].J Antimcrob Chemother,2004,53(6):1076-1080. [13]Thierry N,Daniel A,Patrice N,et al.Chromesome-Encoded NarrowSpectrum Ambler Class A-Lactamase GIL-1 from Citrobacter gillenii[J].J Antimcrob Chemother,2007,51(4):1365-1372. [14]Petrella S,Clermont D,Casin I,et al.Novel class A β-lactamase Sed-1 from Citrobacter sedlakii:genetic diversity of β-lactamases within the Citrobacter genus[J].Antimicrob Agents Chemother,2001,45(8):2287-2298. [15]Brinas L,Lantero M,Alvarez M,et al.Mechanisms of resistance to expanded-spectrum cephalosporins in Escherichia coli isolates recovered in a Spanish hospital[J].J Antimcrob Chemother,2005,56(6):1107-1110.

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  • 收稿日期:  2007-10-10
  • 刊出日期:  2008-03-30
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