Epidemiological and clinical characteristics of confirmed cases of 2009 pandemic influenza A(H1N1) in Jinhua, Zhejiang province, 2009-2010
摘要: 目的 了解浙江省金华市2009-2010年甲型H1N1流感流行病学和临床相关特征,为甲型H1N1流感防治工作提供参考依据。 方法 收集金华市2009-2010年甲型H1N1流感监测资料和现场流行病学调查资料,使用描述流行病学方法分析甲型H1N1流感确诊病例的人群、地区、时间分布,以及重症(危重)病例既往慢病史、并发症、转归等相关临床特征。 结果 2009-2010年金华市共报告甲型H1N1流感确诊病例687例,累计报告发病率为13.5/10万,其中轻症579例,重(危重)病例108例,死亡6例,分别占84.3%、15.7%和0.9%。病例多集中在经济较发达、人口流动较频繁的县(市、区),发病人群以儿童、青少年、学生为主。在不同年龄组的重症(危重)病例中,危症病情发生率不同(2=7.718,df=2,P＜0.05);既往有慢病史有31人,占28.7%,与既往无慢病史者相比,有慢病史者较易发生危症病情(2=6.651,P＜0.05);肺炎、呼吸衰竭、急性呼吸窘迫综合征(ARDS)等为重病(危重)病例主要并发症。 结论 2009-2010年金华市甲型H1N1流感以青少年儿童、轻型感染为多见;甲型H1N1流感病例临床严重性存在年龄分布差异,有慢性疾病史是危重病例发生的危险因素,肺炎、呼吸衰竭、ARDS为甲型H1N1流感主要并发症。Abstract: Objective To analyze the epidemiological and clinical characteristics of confirmed cases of 2009 pandemic influenza A (H1N1) in Jinhua during 2009-2010, and provide evidence for the prevention and control of the disease. Methods The data of surveillance and investigation of 2009 pandemic influenza A (H1N1) virus infection in JInhua during this period were collected to conduct descriptive epidemiological analysis on its time, regional and population distributions, and severe cases chronic medical condition, complication and outcome. Results A total of 687 confirmed cases of 2009 pandemic influenza A (H1N1) were reported with the incidence of 13.5/lakh, 108 were severe cases and 6 were fatal, accounting for 15.7% and 0.9% respectively. Most cases occurred in developed area or area with frequent population floating. The populations affected mostly were children, adolescents and students. The incidence of severe cases differed in different age group(2=7.718,df=2,P＜0.05), and 31 (28.7%) cases were with chronic medical conditions. Patients with chronic medical conditions were more likely to become severe cases (2=6.651,P＜0.05). Pneumonia, respiratory failure and acute respiratory distress syndrome (ARDS) were the main complications. Conclusion The infection of 2009 pandemic influenza A (H1N1) virus was generally mild in Jinhua, which affected children and adolescents mostly. Clinical severity of the infection differed in different age group. Chronic medical condition was one of risk factors of severe cases. Pneumonia, respiratory failure and ARDS were the main complications.
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