Abstract: Objective To understand the prevalence and related risk factors of breast disease in women in the urban area of Jiangmen and provide evidence for the prevention and treatment of breast disease. Methods From May 2009 to December 2010,a breast disease screening was conducted in 12 365 women in the urban area in Jiangmen. Results The prevalence of breast disease in women was 34.51% and the detection rate of breast cancer was 150/lakh. High education level, dysmenorrhea, alcohol use and breast self examination were positively correlated with breast disease (OR=1.10, 1.15, 1.35, 1.12). Late menarche, long menstrual cycle, menopause were negatively correlated with breast diseases (OR=0.96, 0.99, 0.62). Conclusion Child bearing aged women are the key population in breast disease prevention and treatment. Breast disease screening is one of the priorities in women health care, and womens self health care, being married and having baby at appropriate time, having healthy diet and breast self examination, is important to reduce the risk of breast disease.