非O1/O139群霍乱弧菌:流行、致病因子和耐药

李凤娟 阚飙 王多春

李凤娟, 阚飙, 王多春. 非O1/O139群霍乱弧菌:流行、致病因子和耐药[J]. 疾病监测, 2014, 29(3): 239-242. doi: 10.3784/j.issn.1003-9961.2014.03.019
引用本文: 李凤娟, 阚飙, 王多春. 非O1/O139群霍乱弧菌:流行、致病因子和耐药[J]. 疾病监测, 2014, 29(3): 239-242. doi: 10.3784/j.issn.1003-9961.2014.03.019
LI Feng-juan, KAN Biao, WANG Duo-chun. Vibrio cholerae non-O1/O139:Epidemic, virulence factors and drug resistance[J]. Disease Surveillance, 2014, 29(3): 239-242. doi: 10.3784/j.issn.1003-9961.2014.03.019
Citation: LI Feng-juan, KAN Biao, WANG Duo-chun. Vibrio cholerae non-O1/O139:Epidemic, virulence factors and drug resistance[J]. Disease Surveillance, 2014, 29(3): 239-242. doi: 10.3784/j.issn.1003-9961.2014.03.019

非O1/O139群霍乱弧菌:流行、致病因子和耐药

doi: 10.3784/j.issn.1003-9961.2014.03.019
基金项目: 

国家自然科学基金(No.30872260);国家科技重大专项(No.2008ZX10004-012);传染病预防控制国家重点实验室 (No.2011SKLID201)

Vibrio cholerae non-O1/O139:Epidemic, virulence factors and drug resistance

Funds: 

This study was supported by the National Natural Science Foundation (No.30872260), the National Science and Technology Key Project (No.2008ZX10004-012) and the Project of State Key Laboratory for Communicable Disease Prevention and Control (No.2011SKLID201)

  • 摘要: 非O1/O139群霍乱弧菌引起的腹泻在许多发展中国家都有发生,其流行涉及到多个血清群。在有些地方,非O1/O139群霍乱弧菌腹泻的发病率甚至超过了O1/O139群霍乱弧菌腹泻的发病率。非O1/O139群霍乱弧菌的致病因子多种多样,肠毒素、蛋白酶、溶血素和三型分泌系统等被认为是重要的致病因子,但其致病机制非常复杂,至今仍然不完全清楚。随着抗生素使用的增加,出现了许多耐药甚至多重耐药菌株。本研究从非O1/O139群霍乱弧菌腹泻的流行情况、致病因子以及耐药方面加以综述。
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出版历程
  • 收稿日期:  2013-10-12
  • 刊出日期:  2014-03-20

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