上海市蒙得维的亚沙门菌流行特征研究

李勇 王春 唐海丰 王爱敏 黄峥 石维敏 胡雪明 顾宝柯 曾玫 史贤明 阚飙 许学斌

李勇, 王春, 唐海丰, 王爱敏, 黄峥, 石维敏, 胡雪明, 顾宝柯, 曾玫, 史贤明, 阚飙, 许学斌. 上海市蒙得维的亚沙门菌流行特征研究[J]. 疾病监测, 2016, 31(7): 540-545. doi: 10.3784/j.issn.1003-9961.2016.07.004
引用本文: 李勇, 王春, 唐海丰, 王爱敏, 黄峥, 石维敏, 胡雪明, 顾宝柯, 曾玫, 史贤明, 阚飙, 许学斌. 上海市蒙得维的亚沙门菌流行特征研究[J]. 疾病监测, 2016, 31(7): 540-545. doi: 10.3784/j.issn.1003-9961.2016.07.004
LI Yong, WANG Chun, TANG Hai-feng, WANG Ai-min, HUANG Zheng, SHI Wei-min, HU Xue-ming, GU Bao-ke, ZENG Mei, SHI Xian-ming, KAN Biao, XU Xue-bin. Molecular epidemiology and drug susceptibility of Salmonella Montevideo in Shanghai[J]. Disease Surveillance, 2016, 31(7): 540-545. doi: 10.3784/j.issn.1003-9961.2016.07.004
Citation: LI Yong, WANG Chun, TANG Hai-feng, WANG Ai-min, HUANG Zheng, SHI Wei-min, HU Xue-ming, GU Bao-ke, ZENG Mei, SHI Xian-ming, KAN Biao, XU Xue-bin. Molecular epidemiology and drug susceptibility of Salmonella Montevideo in Shanghai[J]. Disease Surveillance, 2016, 31(7): 540-545. doi: 10.3784/j.issn.1003-9961.2016.07.004

上海市蒙得维的亚沙门菌流行特征研究

doi: 10.3784/j.issn.1003-9961.2016.07.004
基金项目: 

国家863项目(No.2012AA101601-4);国家科技重大专项(No.2012ZX10004215-003,2012ZX10004201);中美新发和再发传染病合作项目(No.1U2GGH000961-01);上海市自然科学基金(No.13ZR1404100)

Molecular epidemiology and drug susceptibility of Salmonella Montevideo in Shanghai

Funds: 

This study was supported by the fund for National High Technology Research and Development Project(No.2012AA101601-4), National Key Scientific Research Projects (No. 2012ZX10004215-003, 2012ZX10004201), China-U.S. Collaborative Program on Emerging and Re-emerging in Fectious Diseases(No.1U2GGH000961-01)and Natural Science Foundation of Shanghai(No.13ZR1404100)

  • 摘要: 目的 研究蒙得维的亚沙门菌的耐药及分子流行病学特征。方法 基于上海市针对人群和食源、环境沙门菌的监测基线,分析蒙得维的亚腹泻和食源环境株的耐药表型和分子型特征。结果 蒙得维的亚在本地区的人源和食源沙门菌型数据库中列第24位(32株)和32位(13株)。经实验室确诊的28例蒙得维的亚病例均符合食源性感染特征,易感人群为5岁以下儿童和20~60岁男性,城郊地区高发。人源和食源株均发现对三代头孢(头孢他啶)耐药株,近5年中食源株的多重耐药(MDR)明显增多,28.1%的人源株对环丙沙星处于耐药临界值,来自境外动物制品的蒙得维的亚菌株对抗生素多数敏感。32株人源和13株食源株的分型聚类提示存在优势克隆簇,包括3起经回顾性鉴别诊断的蒙得维的亚的成人暴发,其中2起为多重耐药(MDR-ACSSuT)的克隆暴发。MDR-ACSSuT的人源流行株与甲鱼株之间存在高度的遗传同源性,与境外输入菌株间的耐药和分子型特征差异较大,2个不同克隆簇之间存在遗传进化关系。结论 蒙得维的亚尚未在本地区成为优势种型,但其已通过贸易等方式不断输入国内,逐渐定殖于沿海地区的甲鱼养殖产业链和人群的消费食物链中,最终进化成稳定的MDR和非MDR克隆容易形成分散而隐蔽的食源性暴发。
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出版历程
  • 收稿日期:  2015-11-19
  • 刊出日期:  2016-07-20

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