Would Helicobacter pylori eradication influence dysbiosis of gastrointestinal microbiota
-
摘要: 人体胃肠道是微生物种类最多、功能最强大的微生态系统，胃肠道微生态失衡与多种疾病的发生发展密切相关。人幽门螺杆菌（HP）是定植在胃内的一种致病菌，关于HP感染的处理，多个国际指南或国内共识意见均明确给出了主要包含质子泵抑制剂和2种抗生素的根除方案，随着对HP感染认识的加深和治疗方案的普及，HP根除是否会导致胃肠道微生态的失衡并带来失衡相关后果，这一问题日益受到关注。本文将围绕这一问题进行文献综述并提出自己的认识。Abstract: Gastrointestinal tract is a microecosystem which is inhabited by the largest number of microbiota with most powerful function in human body. The dysbiosis of gastrointestinal microbiota is closely related to the pathogenesis and progression of many diseases. Helicobacter pylori,well-known to us,is a pathogen in stomach. As for the management of H. pylori infection, many international guideline or local consensus have clearly suggested the therapeutic regimens,including H. pylori inhibition with proton pump inhibitor and H. pylori eradication with two antibiotics. As the deepening understanding of H. pylori infection and more common use of its therapeutic regimens,more attention have been paid to whether H. pylori eradication would influence the dysbiosis of gastrointestinal microbiota and related consequences. This paper gives a review of related literatures and summarizes my viewpoints.
-
Key words:
- Helicobacter pylori /
- Eradication /
- Gastrointestinal microbiota
-
[1] Malfertheiner P,Megraud F,O' Morain CA,et al.Management of Helicobacter pylori infection-the Maastricht V/Florence consensus report[J].Gut,2016,66(1):6-30.DOI: 10.1136/gutjnl-2016-312288. [2] Dicksved J, Lindberg M, Rosenquist M, et al.Molecular characterization of the stomach microbiota in patients with gastric cancer and in controls[J].J Med Microbiol,2009,58(Pt 4):509-516.DOI: 10.1099/jmm.0.007302-0. [3] Aviles-Jimenez F,Vazquez-Jimenez F,Medrano-Guzman R,et al.Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer[J].Sci Rep,2014,4:4202.DOI: 10.1038/srep04202. [4] Jakobsson HE,Jernberg C,Andersson AF,et al.Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome[J].PLoS One,2010,5(3):e9836.DOI: 10.1371/journal.pone.0009836. [5] 中华医学会消化病学分会幽门螺杆菌和消化性溃疡学组,全国幽门螺杆菌研究协作组,刘文忠,等.第五次全国幽门螺杆菌感染处理共识报告[J].中华消化杂志,2017,37(6):364-378.DOI:10.3760/cma.j.issn.0254-1432.2017.06.002.Helicobacter Pylori and Peptic Ulcer Group,Gastroenterology Society of Medical Association.The 5th Report of National Consensus on H.pylori infection treatment[J].Chin J Dig, 2017,37(6):364-378.DOI:10.3760/cma.j.issn.0254-1432.2017.06.002. -
点击查看大图
计量
- 文章访问数: 1558
- HTML全文浏览量: 48
- PDF下载量: 26
- 被引次数: 0
下载: