Abstract: Vibrio parahaemolyticus is an important foodborne pathogen. V. parahaemolyticus infections have become a severe global public health problem. As the abuse of antibiotics in aquaculture,animal husbandry and clinic,the pathogen's drug resistance has become a serious problem. Drug-resistant bacteria can infect human beings through food chain,which pose a great challenge to clinical treatment and threat to human health. This review focus on the characteristics,mechanisms and detections of antibiotic resistance of V. parahaemolyticus,which can provide references for other in-depth research about the produce and spread of antibiotic resistance.