张代涛, 杨鹏, 张奕, 马春娜, 卢桂兰, 刘医萌, 赵佳琛, 王全意, 彭晓旻. 2016-2017年北京市A组链球菌耐药特征及相关因素分析[J]. 疾病监测, 2018, 33(11): 955-958. DOI: 10.3784/j.issn.1003-9961.2018.11.017
引用本文: 张代涛, 杨鹏, 张奕, 马春娜, 卢桂兰, 刘医萌, 赵佳琛, 王全意, 彭晓旻. 2016-2017年北京市A组链球菌耐药特征及相关因素分析[J]. 疾病监测, 2018, 33(11): 955-958. DOI: 10.3784/j.issn.1003-9961.2018.11.017
Daitao Zhang, Peng Yang, Yi Zhang, Chunna Ma, Guilan Lu, Yimeng Liu, Jiachen Zhao, Quanyi Wang, Xiaomin Peng. Drug resistance of group A streptococcus and related factors in Beijing, 2016–2017[J]. Disease Surveillance, 2018, 33(11): 955-958. DOI: 10.3784/j.issn.1003-9961.2018.11.017
Citation: Daitao Zhang, Peng Yang, Yi Zhang, Chunna Ma, Guilan Lu, Yimeng Liu, Jiachen Zhao, Quanyi Wang, Xiaomin Peng. Drug resistance of group A streptococcus and related factors in Beijing, 2016–2017[J]. Disease Surveillance, 2018, 33(11): 955-958. DOI: 10.3784/j.issn.1003-9961.2018.11.017

2016-2017年北京市A组链球菌耐药特征及相关因素分析

Drug resistance of group A streptococcus and related factors in Beijing, 2016–2017

  • 摘要:
    目的 分析北京市2016 — 2017年A组链球菌耐药特征及相关影响因素。
    方法 收集北京市2016 — 2017年16个 区分离到的A组链球菌,定量测定青霉素和红霉素等12种抗生素对菌株的最低抑菌浓度(MIC)。
    结果 共对243株A组链球菌进行耐药性检测,菌株对头孢噻肟、青霉素、美洛培南和利奈唑胺的敏感率均为100%;对头孢吡肟、万古霉素的敏感率均为99.18%;对左氧氟沙星和氧氟沙星的敏感率分别为97.53%和90.95%;对红霉素、克林霉素和四环素敏感率分别为1.65%、2.06%和2.88%。
    结论 北京市A组链球菌对大环内酯类抗生素,克林霉素和四环素等仍维持较高的耐药率,对青霉素类、头孢菌素类和喹诺酮类抗生素保持敏感,青霉素仍为治疗该菌感染的首选药物。

     

    Abstract:
    Objective To analyze the drug resistance characteristics of group A streptococcus and related factors in Beijing from 2016 to 2017.
    Methods The minimum inhibitory concentrations of 12 antibiotics to group A streptococcus isolated from 16 districts in Beijing from 2016 to 2017 were tested.
    Results A total of 243 group A streptococcus isolates were tested for drug resistance, and the sensitive rates of the isolates to cefotaxime, penicillin, meropenem and linezolid were 100%. The sensitive rates were 99.18% to cefepime and vancomycin, 97.53% to levofloxacin and 90.95% to ofloxacin. The sensitive rates to erythromycin, clindamycin and tetracycline were 1.65%, 2.06% and 2.88% respectively.
    Conclusion The drug resistance rates of group A streptococcus to macrolides, clindamycin and tetracycline remained at high level in Beijing, while group A streptococcus kept sensitive to penicillin, cephalosporins and quinolones. Penicillin is still the preferred choice for the treatment of group A streptococcus infection.

     

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