Abstract: In May 2019, a total of 54 infectious diseases were reported globally, affecting 98 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were measles (55), dengue fever (31), cholera (10), Chikungunya fever (7) and legionellosis (6). The top four infectious diseases with highest Case Fatality Rates were plague (100.0%), Ebola hemorrhagic fever (67.2%), Middle East respiratory syndrome (34.5%) and Lassa fever (22.4%). The top five infectious diseases with greatest number of deaths were Ebola hemorrhagic fever, cholera, measles, dengue fever and Lassa fever. The prevalent infectious diseases in Africa were Ebola hemorrhagic fever, cholera, yellow fever, Lassa fever and measles, the prevalent infectious diseases in Asia were Middle East respiratory syndrome and dengue fever, the prevalent infectious diseases in America and Europe were dengue fever and measles.