Abstract: In July 2020, a total of 63 infectious diseases were reported globally, affecting 217 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were Coronavirus disease 2019 (COVID-19, 217), dengue fever (35), measles (15), cholera (8) and chikungunya fever (8). The top four infectious diseases with highest case fatality rates were Ebola virus disease (43.1%), plague (21.9%), Lassa fever (20.8%) and COVID-19 (4.0%). The top five infectious diseases with greatest number of deaths were COVID-19, cholera, dengue fever, measles and Ebola virus disease. The prevalent infectious diseases in Asia were COVID-19 and dengue fever, the prevalent infectious diseases in Africa were COVID-19, Ebola virus disease, plague, cholera, yellow fever, Lassa fever and measles, the prevalent infectious diseases in America were COVID-19 and dengue fever, the prevalent infectious diseases in Europe were COVID-19 and measles.